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Principal Scientist/Director, Biomarker/Bioanalytical

Stevenage, UK (On-Site) 

The Company 

Complement Therapeutics (CTx) is an exciting early-stage biotechnology company focused on the research and development of novel therapeutics for complement-mediated diseases. The Company is a spinout from the University of Manchester and is based on the pioneering research of its founders into novel targets within the complement cascade. 

Our lead investigational product (CTx001) is being evaluated as a potential gene therapy for dry age-related macular degeneration/geographic atrophy, a leading cause of blindness. Additional programmes will evaluate potential therapeutic opportunities in other complement-mediated conditions. 

The Company is also developing a unique quantification methodology, the Complement Precision Medicine (CPM) platform, to enable the quantification of over 30 complement cascade proteins enabling more precise diagnosis and monitoring of disease. 

The role 

This is an exciting opportunity to join the Company in a pivotal strategic role to drive the non-clinical development of our novel pipeline. 

In this role you will be responsible for management of bioanalytical method development and validation in support of pipeline projects. You will also be contributing to biomarker discovery and development efforts in support of preclinical and clinical programs. 

Key responsibilities and learning opportunities 

  • Establish and implement bioanalytical strategy to quantify drug exposure and track pharmacodynamics in vivo 
  • Collaborate with Pharmacology and Bioanalytical groups to help build a holistic research strategy 
  • Oversee method qualification and validation in support of IND enabling studies 
  • Explore and develop biomarkers of target engagement and pharmacodynamic response 
  • Contribute to regulatory filings 
  • Majority based in the lab in Stevenage 
  • Reports to CSO 

Qualifications and Experience: 

  • Holds a PhD with 7+ years of industry experience. 
  • Significant platform expertise (LC-MS/MS, immunoassay and other) 
  • Significant experience managing CROs 
  • Data management and report generation 
  • Comfortable in a highly matrixed environment 
  • Familiarity with working in a regulated environment and contributing to regulatory filings. 
  • Understanding of complement biology and/or ophthalmology preferred 
  • Project and people management  
  • Cross functional experience in clinical development programs 
  • Excellent organisational and communication skills, both written and oral 
  • A self-starter, self-motivated individual who is adept at working in fast-paced environments 

To Apply 

Please fill in this form ( You must also include a cover letter detailing why you are interested in joining a biotech start-up and then Complement Therapeutics in particular. Your cover letter should be no more than one page of A4.

Job Category: R&D
Job Type: Full Time
Job Location: On-site Stevenage