Skip to main content

Principal Scientist/Director, Pharmacology

Stevenage, UK (On-Site) 

The Company 

Complement Therapeutics (CTx) is an exciting early-stage biotechnology company focused on the research and development of novel therapeutics for complement-mediated diseases. The Company is a spinout from the University of Manchester and is based on the pioneering research of its founders into novel targets within the complement cascade. 

Our lead investigational product (CTx001) is being evaluated as a potential gene therapy for dry age-related macular degeneration/geographic atrophy, a leading cause of blindness. Additional programmes will evaluate potential therapeutic opportunities in other complement-mediated conditions. 

The Company is also developing a unique quantification methodology, the Complement Precision Medicine (CPM) platform, to enable the quantification of over 30 complement cascade proteins enabling more precise diagnosis and monitoring of disease. 

The role 

This is an exciting opportunity to join the Company in a pivotal strategic role to drive the non-clinical development of our novel pipeline. 

This laboratory-based role will be responsible for establishing an integrated pharmacology strategy in support of preclinical and clinical development pipeline programs. 

Key responsibilities and learning opportunities: 

  • Establish and implement research strategy to progress pipeline programs to proof of concept 
  • Collaborate with DMPK and Bioanalytical group to help model PK/PD relationships for pipeline compounds 
  • Establish in vitro and in vivo methods to demonstrate therapeutic proof of concept and progress programs from discovery through lead identification/optimization and nomination of development candidate 
  • Contribute to regulatory filings 
  • Will be majority lab-based in Stevenage  
  • Mentor junior scientists 
  • Reports to CSO  

Qualifications and Experience: 

  • PhD with 7+ years of industry experience in drug discovery and development, including experience managing direct reports and running project teams 
  •  Project and people management experience 
  • Expertise in animal models of disease and translational pharmacology models such as iPSC derived cell lines and primary cell/organoid culture systems 
  • Demonstrated ability to progress drug discovery projects from lead identification through lead optimization and development candidate nomination 
  • Ability to lead cross-functional project teams; comfortable in a highly matrixed environment; excellent communication skills 
  • Familiarity with working in a regulated environment and contributing to regulatory filings 
  • Understanding of complement biology and/or ophthalmology preferred 
  • Project and people management 
  • Cross functional experience in clinical development programs 
  • Excellent organisational and communication skills, both written and oral 
  • A self-starter, self-motivated individual who is adept at working in fast-paced environments 

To Apply 

Please fill in this form ( You must also include a cover letter detailing why you are interested in joining a biotech start-up and then Complement Therapeutics in particular. Your cover letter should be no more than one page of A4.

Job Category: R&D
Job Type: Full Time
Job Location: On-site Stevenage

Apply for this position

Allowed Type(s): .pdf, .doc, .docx